In general, "Hybrid" refers to a system in which two separate technologies are combined with one another. The Hybrid Audio Engine in Samplitude includes a combination of a low latency and the classical Samplitude playback engine with higher latency where a clearly defined signal flow between the two exists.

The Low Latency Engine reduces response times when calculating track effects and enables Live Monitoring at lower latencies. The integrated classical playback engine on the other hand increases performance which allows the integration of sophisticated object effects, object auxiliaries, and object surround functions. The Hybrid Audio Engine is based on the ASIO driver system and, thanks to its low input/output delay at the same performance levels, optimizes the system especially when working with software instruments and other plug-ins.

Go to System Settings (keyboard shortcut "Y") >"Audio Setup" > "Driver System" and select "ASIO". While ASIO generally ensures that latency, independent of the hardware load, does not accept values that are too large, a low latency function can also be used if you tick the "Hybrid Engine"/"Performance Mixer" box in the Monitoring settings.
The hybrid engine facilitates audio monitoring including track effects in the record track and also calculates the playback tracks at short latency times. Thus the entire Mixer can operate in Low Latency mode, including the bus and master effects, and can be used for editing input signals.